Erbb3 is involved in activation

Requirement for neuregulin receptor erbB2 in neural and cardiac development. Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. The ubiquitin ligase Nedd is required for heart development and is a suppressor of thrombospondin J Biol Chem.

ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. ErbB3 is required for ductal morphogenesis in the mouse mammary gland. Breast Cancer Res. The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor.

A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

Mol Cell Biol. ErbB3 HER3 interaction with the p85 regulatory subunit of phosphoinositide 3-kinase. Biochemical J. Cancer Res. Expression of the ERBB3 gene product in breast cancer.

Brit J Cancer. Expression of the HER family of receptor tyrosine kinases in breast cancer. J Pathol. Expression of c-erbB3 protein in primary breast carcinomas.

Oncogenic ERBB3 mutations in human cancers. ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas. Int J Cancer. Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Expression of the c-erbB-3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1. BMC Caner.

Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells. Expression of metastasis-related nmH1 and nmH2 genes in ovarian carcinomas: correlation with clinicopathology, EGFR, c-erbB-2, and c-erbB-3 genes, and sex steroid receptor expression.

Clin Mol Pathol. Neuregulin expression, function, and signaling in human ovarian cancer cells. ErbB-3 predicts survival in ovarian cancer. High c-erbB-3 protein expression is associated with shorter survival in advanced non-small cell lung carcinomas. Mod Pathol. Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer. Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.

Gyorffy B, Lage H. A Web-based data warehouse on gene expression in human malignant melanoma. J invest Derma. Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med. Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis.

Expression and nuclear localization of ErbB3 in prostate cancer. Sci Amer. Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene.

HER3 overexpression and survival in solid tumors: a meta-analysis. J Nat Can Inst. Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer. EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. Mol Cancer Thera. Int J Oncol. Cancer Med. Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer.

Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells. Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. Novel anti-ErbB3 monoclonal antibodies show therapeutic efficacy in xenografted and spontaneous mouse tumors. Phosphotyrosine interactome of the ErbB-receptor kinase family.

Mol Sys Biol. A quantitative protein interaction network for the ErbB receptors using protein microarrays. HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation. Scott G. Biochem Biophys Res Commun. Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer. Ciechanover A. The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting.

Ubiquitin-binding domains - from structures to functions. Nat Rev Mol Cell Biol. The spatial and temporal organization of ubiquitin networks. Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma. Pros Cancer and Prostat Dis. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Lipkowitz S, Weissman AM. Mani A, Gelmann EP. The ubiquitin-proteasome pathway and its role in cancer.

Ravid T, Hochstrasser M. Diversity of degradation signals in the ubiquitin-proteasome system. Cbl: many adaptations to regulate protein tyrosine kinases. Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer.

Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Comm. Rotin D, Kumar S.

Physiological functions of the HECT family of ubiquitin ligases. The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Rizo J, Sudhof TC. Mechanics of membrane fusion. Nat Struct Biol. Characterizing Class I WW domains defines key specificity determinants and generates mutant domains with novel specificities. Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan. Nedd binds and ubiquitylates activated FGFR1 to control its endocytosis and function.

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. EMBO Rep. FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors. Meroni G, Diez-Roux G. The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells. A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.

Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

Regulation of neuronal survival by the serine-threonine protein kinase Akt. Eur J Cancer. Genes Dev. Br J Cancer. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Activated neu induces rapid tumor progression. Reactivity of monoclonal antibodies against intermediate filament proteins during embryonic development.

J Embryol Exp Morphol. Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product.

Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Synergistic interaction of pc-neu and the EGF receptor leads to transformation of rodent fibroblasts. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

A novel splice variant of HER2 with increased transformation activity. Mol Carcinog. Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer. Expression of the ERBB3 gene product in breast cancer. Nat Genet. Early and multifocal tumors in breast, salivary, harderian and epididymal tissues developed in MMTY-Neu transgenic mice.

Cancer Lett. Am J Hum Genet. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes.

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas. Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR EMBO J. Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells.

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U, or GTP gamma S. Anti-phosphotyrosine immunoprecipitation of phosphatidylinositol 3' kinase activity in different cell types after exposure to epidermal growth factor. Biochem Biophys Res Commun. Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. Relationship between phosphoinositide kinase activities and protein tyrosine phosphorylation in plasma membranes from A cells.

Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation. Epidermal growth factor-activated calcium and potassium channels. Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA Leydig tumor cells. Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A cells. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

Expression of the c-erbB-3 protein in normal human adult and fetal tissues. Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells. After insulin binds. Activation of phosphatidylinositol 3-kinase by insulin. SH2 domains recognize specific phosphopeptide sequences. Expression and function of IRS-1 in insulin signal transmission. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.

Separation and characterization of a phosphatidylinositol kinase activity that co-purifies with the epidermal growth factor receptor. Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils.

CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium. Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. Growth factor receptor tyrosine kinases. Annu Rev Biochem. Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositolkinase.

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